Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression
Yang Lu, Jian Gao, Peipei Wang, Haifeng Chen, Xinjun He, Mengxin Luo, Yu Guo, Linjie Li, Weihao Zhuang, Bo Zhang, Nengming Lin, Jia Li, Yubo Zhou, Xiaowu Dong, Jinxin Che
Topics & Concepts
UbiquitinChemistryCancer researchCell growthDownregulation and upregulationHepatocellular carcinomaApoptosisProteaseDeubiquitinating enzymeCell biologyCell cultureEnzymeBiochemistryBiologyGeneGeneticsUbiquitin and proteasome pathwaysHippo pathway signaling and YAP/TAZCancer-related Molecular Pathways