Walnut polyphenols and the active metabolite urolithin A improve oxidative damage in SH-SY5Y cells by up-regulating PKA/CREB/BDNF signaling
Lei An, Mengxue Li, Cunen Zou, Ke Wang, Wei Zhang, Xiaolong Huang, Yousheng Wang
Abstract
treatment. Furthermore, pretreatment with the PKA inhibitor H89 abolished the protective effects of WP and UroA, indicating that up-regulation of the PKA/CREB/BDNF neurotrophic signaling pathway is required for their neuroprotective effects against oxidative stress. The current work provides new perspectives for understanding the beneficial effects of WP and UroA on brain function, which warrants further investigation.
Topics & Concepts
SH-SY5YCREBMetaboliteChemistryPolyphenolOxidative damagePharmacologyOxidative phosphorylationBiochemistryOxidative stressAntioxidantBiologyNeuroblastomaTranscription factorCell cultureGeneticsGenePomegranate: compositions and health benefitsPhytochemicals and Antioxidant ActivitiesAntioxidant Activity and Oxidative Stress