The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) mRNA Vaccine-Breakthrough Infection Phenotype Includes Significant Symptoms, Live Virus Shedding, and Viral Genetic Diversity
Simon Pollett, Stephanie A Richard, Anthony C Fries, Mark P. Simons, Katrin Mende, Tahaniyat Lalani, Tida Lee, Sharon Chi, Rupal Mody, Cristian Madar, Anuradha Ganesan, Derek Larson, Christopher Colombo, Rhonda E Colombo, E Samuels, Christopher C. Broder, Eric D. Laing, Darci R. Smith, David R. Tribble, Brian K. Agan, Timothy Burgess
Abstract
Little is known about severe acute respiratory syndrome coronavirus 2 "vaccine-breakthrough" infections (VBIs). Here we characterize 24 VBIs in predominantly young healthy persons. While none required hospitalization, a proportion endorsed severe symptoms and shed live virus as high as 4.13 × 103 plaque-forming units/mL. Infecting genotypes included both variant-of-concern (VOC) and non-VOC strains.
Topics & Concepts
VirologyMedicineViral sheddingSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirusCoronavirusCoronavirus disease 2019 (COVID-19)Attenuated vaccine2019-20 coronavirus outbreakRespiratory systemImmunologyBiologyOutbreakVirulenceGeneInternal medicineGeneticsInfectious disease (medical specialty)DiseaseSARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral gastroenteritis research and epidemiology