Small Airway Disease and Emphysema Are Associated with Future Exacerbations in Smokers with CT-derived Bronchiectasis and COPD: Results from the COPDGene Cohort
Diego J. Maselli, Andrew Yen, Wei Wang, Yuka Okajima, W.R. Dolliver, Christina Mercugliano, Antonio Anzueto, Marcos I. Restrepo, Timothy R. Aksamit, Ashwin Basavaraj, Stefano Aliberti, Kendra A. Young, Gregory L. Kinney, J. Michael Wells, Raúl San Jośe Estépar, David A. Lynch, Alejandro A. Díaz
Abstract
≤ .001 for both). Conclusion In smokers with CT-derived bronchiectasis and chronic obstructive pulmonary disease, structural damage to lung parenchyma and small airways was associated with a higher number of exacerbations per year. Clinical trial registration no. NCT00608764 © RSNA, 2021.
Topics & Concepts
MedicineBronchiectasisInterquartile rangeExacerbationCOPDInternal medicineSeverity of illnessBody mass indexProspective cohort studyCohortLungChronic Obstructive Pulmonary Disease (COPD) ResearchCystic Fibrosis Research AdvancesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis