Photoactivated hydride therapy under hypoxia beyond ROS
Xia Wang, Yijian Gao, Ting Wang, Zhaobin Wang, Hang He, Shengliang Li, Fude Feng
Abstract
NADH-dependent photoactivation of pyridinium-modified zinc porphyrin in cancer cells into zinc phlorin with strong hydride donating capability leads to mitochondrial dysfunction, paving a way for reductive phototherapy beyond ROS under hypoxia.
Topics & Concepts
Hypoxia (environmental)HydrideChemistryCombinatorial chemistryOxygenOrganic chemistryHydrogenAdenosine and Purinergic SignalingNanoplatforms for cancer theranosticsAnesthesia and Neurotoxicity Research