Chemoenzymatic and Protecting-Group-Free Synthesis of 1,4-Substituted 1,2,3-Triazole-α-<scp>d</scp>-glucosides with Potent Inhibitory Activity toward Lysosomal α-Glucosidase
Jaggaiah N. Gorantla, Maniganda Santhi, Salila Pengthaisong, Lukana Ngiwsara, Phannee Sawangareetrakul, Suwadee Chokchaisiri, Prasat Kittakoop, Jisnuson Svasti, James R. Ketudat Cairns
Abstract
more than 60-fold lower than that of the commercial α-glucosidase inhibitor acarbose.
Topics & Concepts
ChemistryAzideSodium azideClick chemistryStereochemistryGlucosideProtecting groupArylAmideOrganic chemistryAlternative medicineAlkylMedicinePathologyCarbohydrate Chemistry and SynthesisClick Chemistry and ApplicationsTransgenic Plants and Applications