Litcius/Paper detail

Preparation, Structure, and Reactivity of Pseudocyclic β‐Trifluorosulfonyloxy Vinylbenziodoxolone Derivatives

Akira Yoshimura, Christopher D. Huss, Mackenzie Liebl, Gregory T. Rohde, Scott M. Larson, Gunnar B. Frahm, Mattew W. Luedtke, Tanner J. Schumacher, Zachary Gardner, Viktor V. Zhdankin, Павел С. Постников, Mekhman S. Yusubov, Tsugio Kitamura, Akio Saito

2021Advanced Synthesis & Catalysis17 citationsDOI

Abstract

Abstract Pseudocyclic β‐trifluorosulfonyloxy vinylbenziodoxolones were prepared starting from hydroxybenziodoxolones and alkynes in the presence of trifluoromethanesulfonic acid. The reaction of these compounds with azide anion leads to β‐azido vinylbenziodoxolones as products of vinylic nucleophilic substitution in which addition‐elimination reactions occur and the double bond configuration is retained. The structures of β‐trifluorosulfonyloxy vinylbenziodoxolone and β‐azido vinylbenziodoxolone were established by single crystal X‐ray diffraction. magnified image

Topics & Concepts

ChemistryAzideReactivity (psychology)Double bondNucleophilic substitutionCrystal structureOrganic chemistrySingle crystalNucleophileMedicinal chemistryStereochemistryCatalysisCrystallographyAlternative medicinePathologyMedicineOxidative Organic Chemistry ReactionsFluorine in Organic ChemistrySynthesis and Catalytic Reactions