Chiral recognition of amino-acid esters by a glucose-derived macrocyclic receptor
Pit Dominique, Martin Schnurr, Bartosz Lewandowski
Abstract
We report a glucose-based crown ether capable of chiral recognition of a wide range of amino-acid methyl esters in aqueous environments. The enantioselectivities towards amino-acids with extended hydrophobic side chains displayed by the glucose-derived macrocycle are among the highest observed for small molecule synthetic receptors to date.
Topics & Concepts
ChemistryEnantioselective synthesisAmino acidReceptorScaffoldSmall moleculeStereochemistryMolecular recognitionMoleculeCombinatorial chemistryBiochemistryOrganic chemistryCatalysisBiomedical engineeringMedicineChemical Synthesis and AnalysisAnalytical Chemistry and ChromatographyMolecular Sensors and Ion Detection