Precise Detection and Quantitative Prediction of Blood Glucose Level With an Electronic Nose System
Zhenyi Ye, Jie Wang, Hao Hua, Xiangdong Zhou, Qiliang Li
Abstract
Blood glucose level is an important health indicator. Non-invasive, easy-to-use glucose detection and monitoring methods and tools are desperately needed, especially for patients with diabetes. In this work, we developed a new method to quantitively identify and analyze the blood glucose level by measuring the biomarkers in breath with an electronic nose (E-Nose) system based on a metal oxide (MOX) gas sensor array. Advanced machine-learning models have been studied and developed to precisely predict the blood glucose level based on the measurement of 41 participants for 10 days. The testing result shows that the E-Nose system and proposed analysis models identify blood glucose levels at an accuracy of 90.4% and a small average error of 0.69 mmol/L in blood glucose concentration. This study indicates that the E-Nose system enabled with machine learning is an efficient and precise method to achieve low-cost and non-invasive disease diagnosis.