Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system
Peng Yin, Dazhang Bai, Longhong Zhu, Fuyu Deng, Xiangyu Guo, Bang Li, Laiqiang Chen, Shihua Li, Xiaojiang Li
Topics & Concepts
CytoplasmFrontotemporal lobar degenerationUbiquitinProteasomeMutantAmyotrophic lateral sclerosisCell biologyImmunoprecipitationBiologyCytoplasmic inclusionChemistryMolecular biologyBiochemistryPathologyFrontotemporal dementiaMedicineGeneDementiaDiseaseAmyotrophic Lateral Sclerosis ResearchParkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways