Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic <i>KRAS</i> mutant colon cancer
Aiora Cenigaonandia‐Campillo, Roberto Serna‐Blasco, Laura Gómez-Ocabo, Sonia Solanes‐Casado, Natalia Baños‐Herraiz, Laura del Puerto‐Nevado, J. A. Cañas, María Jesús Fernández‐Aceñero, Jesús García‐Foncillas, Óscar Aguilera
Abstract
mutant colon cancer. Potential impact of vitamin C in the clinical management of anti-EGFR chemoresistant colorectal neoplasias should be further considered.
Topics & Concepts
Citric acid cycleCancer researchChemistryWestern blotBiologyMolecular biologyBiochemistryMetabolismGeneCancer, Hypoxia, and MetabolismVitamin C and Antioxidants ResearchATP Synthase and ATPases Research