Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors
Simona Ponzi, Federica Ferrigno, Monica Bisbocci, Cristina Alli, Jesus M. Ontoria, Alessia Petrocchi, Carlo Toniatti, Esther Torrente
Topics & Concepts
Allosteric regulationChemistryChemical biologyComputational biologyDrug discoveryMoietyNucleophilic aromatic substitutionChemical synthesisProtein tyrosine phosphataseCombinatorial chemistryBiochemistryEnzymeStereochemistryIn vitroBiologyOrganic chemistryNucleophilic substitutionProtein Tyrosine PhosphatasesBioactive Compounds and Antitumor AgentsGalectins and Cancer Biology