Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development
Wei Ge, Shao‐Jing Tan, Shan-He Wang, Lan Li, Xiao-Feng Sun, Wei Shen, Xin Wang
Abstract
Our findings here provide a molecular landscape during hair follicle epithelium/dermal cell lineage fate decisions, and recapitulate the sequential activation of core regulatory transcriptional factors (TFs) in different cell populations during hair follicle morphogenesis. More importantly, our study here represents a valuable resource for understanding the molecular pathways involved during hair follicle de novo morphogenesis, which will have implications for future hair loss treatments.
Topics & Concepts
BiologyCell fate determinationMorphogenesisHair follicleCell biologyTranscriptomeCellular differentiationEmbryonic stem cellGene expression profilingCell typeFate mappingCellSingle-cell analysisGene expressionGeneticsStem cellProgenitor cellTranscription factorGeneHair Growth and DisordersCancer and Skin Lesions