Structural basis of PROTAC cooperative recognition for selective protein degradation
Morgan S. Gadd, Andrea Testa, Xavier Lucas, Kwok-Ho Chan, Wenzhang Chen, Douglas J. Lamont, Michael Zengerle, Alessio Ciulli
Topics & Concepts
Ternary complexUbiquitin ligaseIsothermal titration calorimetryBromodomainDNA ligaseChemistryProtein degradationUbiquitinProteolysisBiochemistrySmall moleculePlasma protein bindingMutagenesisBifunctionalBiophysicsUbiquitin-Protein LigasesCell biologyBiologyDNAMutationEnzymeHistoneCatalysisGeneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis