Apoptotic vesicle-mediated senolytics requires mechanical loading
Zhulin Xue, Yexiang Jiang, Bowen Meng, Lu Lu, Hao Meng, Yi Zhang, Songtao Shi, Zili Li, Xueli Mao
Abstract
This study identified a previously unknown role of mechanical force in maintaining apoptotic homeostasis and eliminating senescent cells. Systemic infusion of mesenchymal stem cell-derived apoVs can effectively rescue apoptotic resistance and eliminate senescent cells in mechanical unloading mice.
Topics & Concepts
ApoptosisVesicleCell biologyChemistryBiophysicsNanotechnologyMaterials scienceBiologyBiochemistryMembraneRNA Interference and Gene DeliveryPhagocytosis and Immune RegulationCancer Research and Treatments