Camptothecin structure simplification elaborated new imidazo[2,1-b]quinazoline derivative as a human topoisomerase I inhibitor with efficacy against bone cancer cells and colon adenocarcinoma
Ahmed I. Khodair, Salwa M. El‐Hallouty, Brittnee Cagle-White, May H. Abdel Aziz, Mahmoud Kh. Hanafy, Samar Mowafy, Nadia Μ. Hamdy, Shaymaa E. Kassab
Topics & Concepts
CamptothecinChemistryTopoisomeraseMTT assayCytotoxicityCancer cellTopotecanStereochemistryBiochemistryPharmacologyCancerCell growthDNAIn vitroBiologyGeneticsChemotherapyCancer therapeutics and mechanismsQuinazolinone synthesis and applicationsLung Cancer Treatments and Mutations