Assessment of the CYP1A2 Inhibition-Mediated Drug Interaction Potential for Pinocembrin Using <i>In Silico</i>, <i>In Vitro</i>, and <i>In Vivo</i> Approaches
Shipra Bhatt, Sumit Dhiman, Vinay Kumar, Abhishek Gour, Diksha Manhas, Kuhu Sharma, Probir Kumar Ojha, Utpal Nandi
Abstract
investigations using a rat model, pinocembrin displayed a marked alteration in the plasma exposure of CYP1A2 substrate drugs, namely, caffeine and tacrine. In conclusion, pinocembrin has a potent CYP1A2 inhibitory action to cause drug interactions, and further confirmatory study is warranted at the clinical level.
Topics & Concepts
In silicoPinocembrinIn vivoIn vitroCYP1A2PharmacologyChemistryDrugComputational biologyBiologyBiochemistryGeneticsFlavonoidGeneMicrosomeAntioxidantPharmacogenetics and Drug MetabolismNeurotransmitter Receptor Influence on BehaviorCholinesterase and Neurodegenerative Diseases