Amides Activation: Transition Metal‐Free Coupling Between <scp>CN</scp> Activated Amides and Enolizable Amides
Devaneyan Joseph, Min Seok Oh, Aravindan Jayaraman, Sunwoo Lee
Abstract
Transition metal‐free Claisen‐type condensation between two different amides was developed. N ‐phenyl‐ N ‐tosylbenzamide derivatives reacted with enolizable amides such as N ‐methyl pyrrolidinone and N , N ‐dimethyl acetamide in the presence of NaHMDS to give their corresponding β ‐ketoamides with moderate‐to‐good yields.
Topics & Concepts
AcetamideTransition metalChemistryCondensationMetalAmideMedicinal chemistryPolymer chemistryStereochemistryCombinatorial chemistryOrganic chemistryCatalysisPhysicsThermodynamicsAdvanced Synthetic Organic ChemistryChemical Synthesis and AnalysisAsymmetric Hydrogenation and Catalysis