Ursolic acid promotes microglial polarization toward the M2 phenotype via PPARγ regulation of MMP2 transcription
Yuye Wang, Yuye Wang, Luying Qiu, Shumin Deng, Fang Liu, Zhiyi He, Mengye Li, Yanzhe Wang, Yanzhe Wang
Topics & Concepts
MicrogliaPeroxisome proliferator-activated receptorMMP9ThiazolidinedioneChemistryMMP2Nuclear receptorInflammationReceptorTranscription factorCell biologyCancer researchBiologyDownregulation and upregulationEndocrinologyBiochemistryImmunologyType 2 diabetesDiabetes mellitusGeneNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerInflammation biomarkers and pathways