Optimization of solid self-dispersing micelle for enhancing dissolution and oral bioavailability of valsartan using Box-Behnken design
Yoon Tae Goo, Sun Young Park, Bo Ram Chae, Ho Yub Yoon, Chang‐Hyun Kim, Ji Yeh Choi, Seh Hyon Song, Young Wook Choi
Topics & Concepts
BioavailabilityBox–Behnken designDissolutionChromatographyPoloxamerPoloxamer 407MicelleMaterials scienceCentral composite designCritical micelle concentrationChemistryDosage formResponse surface methodologyPharmacologyPolymerCopolymerOrganic chemistryMedicineComposite materialAqueous solutionDrug Solubulity and Delivery SystemsCrystallization and Solubility StudiesDrug Transport and Resistance Mechanisms