Iodine-mediated oxythiolation of <i>o</i>-vinylanilides with disulfides for the synthesis of benzoxazines
Yu Yang, Liyan Liu, Kuiliang Li, Zhenggen Zha, Qi Sun, Zhiyong Wang
Abstract
-vinylanilides with disulfides was developed. By virtue of this method, a series of thio-tethered benzoxazine derivatives were synthesized in good to excellent yields. The reaction features high yields, is metal-free, and has a wide substrate scope.
Topics & Concepts
IodineChemistryMedicinal chemistryCombinatorial chemistryOrganic chemistrySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods