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Pirtobrutinib, a highly selective, non-covalent (reversible) BTK inhibitor in patients with B-cell malignancies: analysis of the Richter transformation subgroup from the multicentre, open-label, phase 1/2 BRUIN study

William G. Wierda, Nirav N. Shah, Chan Y. Cheah, David Lewis, Marc Hoffmann, Catherine C. Coombs, Nicole Lamanna, Shuo Ma, Deepa Jagadeesh, Talha Munir, Yucai Wang, Toby A. Eyre, Joanna Rhodes, Matthew McKinney, Ewa Lech‐Marańda, Constantine S. Tam, Wojciech Jurczak, Koji Izutsu, Alvaro J. Alencar, Manish Patel, John F. Seymour, Jennifer A. Woyach, Philip A. Thompson, Paolo Abada, Caleb Ho, Samuel McNeely, Narasimha Marella, Bastien Nguyen, Chunxiao Wang, Amy S. Ruppert, Binoj C. Nair, Hui Liu, Donald E. Tsai, Lindsey E. Roeker, Paolo Ghia

2024The Lancet Haematology37 citationsDOI

Topics & Concepts

MedicineBruton's tyrosine kinaseIbrutinibTolerabilityChronic lymphocytic leukemiaInternal medicineRefractory (planetary science)Subgroup analysisOncologyPhases of clinical researchAdverse effectClinical trialTyrosine kinaseLeukemiaMeta-analysisAstrobiologyReceptorPhysicsChronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and TreatmentHER2/EGFR in Cancer Research
Pirtobrutinib, a highly selective, non-covalent (reversible) BTK inhibitor in patients with B-cell malignancies: analysis of the Richter transformation subgroup from the multicentre, open-label, phase 1/2 BRUIN study | Litcius