Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer
Hiroyuki Araki, Hiroshi Tazawa, Nobuhiko Kanaya, Yoshinori Kajiwara, Motohiko Yamada, Masashi Hashimoto, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Yuzo Umeda, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara
Abstract
experiments would be warranted to evaluate the survival benefit of tumor-bearing mice in combination therapy with OBP-702 and PD-1 blockade.
Topics & Concepts
Oncolytic virusImmunogenic cell deathBlockadeCancer researchImmune checkpointImmune systemPancreatic cancerOncolytic adenovirusApoptosisProgrammed cell deathMedicineCancerBiologyImmunotherapyImmunologyInternal medicineReceptorBiochemistryVirus-based gene therapy researchCancer Research and TreatmentsCAR-T cell therapy research