Unorthodox cascade reaction of arynes and <i>N</i>-nitrosamides leading to indazole scaffolds
Popuri Sureshbabu, Vinod Bhajammanavar, Venkata Surya Kumar Choutipalli, V. Subramanian, Mahiuddin Baidya
Abstract
)-H bond functionalization strategies under transition-metal-free conditions at ambient temperature, offering functionalized indazoles in high yields and regioselectivity. The protocol is scalable and exhibits a broad substrate scope. The reaction mechanism is also studied with DFT calculations.
Topics & Concepts
AryneCascade reactionRegioselectivityIndazoleChemistryCascadeAnnulationCombinatorial chemistrySubstrate (aquarium)Surface modificationComputational chemistryStereochemistryMedicinal chemistryOrganic chemistryCatalysisPhysical chemistryChromatographyOceanographyGeologyCyclization and Aryne ChemistryCatalytic Alkyne ReactionsChemical Reactions and Mechanisms