Exosomal long non-coding RNA MSTRG.292666.16 is associated with osimertinib (AZD9291) resistance in non-small cell lung cancer
Qinfang Deng, Qiyu Fang, Boxiong Xie, Hui Sun, Yuchen Bao, Songwen Zhou
Abstract
. Knockdown of lncRNA MSTRG.292666.16 decreased osimertinib resistance of H1975R cells. Our results suggest that exosomal lncRNA MSTRG.292666.16 might be associated with osimertinib resistance in NSCLC.
Topics & Concepts
OsimertinibMicrovesiclesGene knockdownLung cancerCancer researchDownregulation and upregulationExosomemicroRNAGeneBiologyMedicineMutationInternal medicineGeneticsKRASCancer-related molecular mechanisms researchCircular RNAs in diseasesCholangiocarcinoma and Gallbladder Cancer Studies