Feeding mode influences dynamic gut microbiota signatures and affects susceptibility to anti-CD3 mAb-induced intestinal injury in neonatal mice
Saravanan Subramanian, Hua Geng, Chao Du, Pauline M. Chou, Heng‐Fu Bu, Xiao Wang, Suchitra Swaminathan, Stephanie Tan, Jason M. Ridlon, Isabelle G. De Plaen, Xiao‐Di Tan
2022American Journal of Physiology-Gastrointestinal and Liver Physiology10 citationsDOIOpen Access PDF
Abstract
This report shows that a feeding mode profoundly affects gut colonization in neonatal mice. Furthermore, our results demonstrate that formula feeding predisposes mouse pups to anti-CD3 mAb-induced necrotizing enterocolitis (NEC)-like intestinal injury upon inadequate microbial colonization. The study suggests the role of the combined presence of formula feeding-associated dysbiosis and mucosal inflammation in the pathogenesis of NEC and provides a new mouse model to study this disease.
Topics & Concepts
Necrotizing enterocolitisColonizationDysbiosisBiologyImmunologyPathogenesisGut floraEnterocolitisInflammationMedicineMicrobiologyPathologyInternal medicineInfant Nutrition and HealthGut microbiota and healthViral gastroenteritis research and epidemiology