Development and Validation of a Stability-Indicating UV Spectroscopic Method for Baricitinib in Bulk and Formulation
Khagga Bhavya Sri, Mohammad Saba Fatima, Mogili Sumakanth
Abstract
Baricitinib is a novel therapeutic agent recently approved for the treatment of moderate to severe rheumatoid arthritis, severe alopecia areata, and since 2022, COVID-19 in hospitalized adults requiring supplemental oxygen. This drug acts as a selective inhibitor of Janus kinase 1 and 2. This study aimed to establish and validate a stability-indicating UV spectroscopic method for the measurement of baricitinib in both bulk and formulated forms. A straightforward, precise, and cost-effective UV m
Topics & Concepts
Stability (learning theory)Materials scienceApplied mathematicsComputer scienceBiological systemMathematicsMachine learningBiologyProtein purification and stabilityPharmacological Effects of Natural CompoundsComputational Drug Discovery Methods