Sphingosine 1-phosphate (S1P) produced by sphingosine kinase 1 (SphK1) and exported via ABCC1 is related to hepatocellular carcinoma (HCC) progression.
Vikas Satyananda, Masanori Oshi, Yoshihisa Tokumaru, Aparna Maiti, Nitai C. Hait, Ryusei Matsuyama, Itaru Endo, Kazuaki Takabe
Abstract
= 0.004) compared to low S1P export group. In conclusion, simultaneous high expression of SphK1 and ABCC1 that reflect S1P export is associated with enhancement of both HCC progression and immune response. Given that S1P export was also associated with worse survival, we cannot help but speculate that pro-cancer pathways activated by S1P may overwhelm the anti-cancer immune response mediated by S1P.
Topics & Concepts
Sphingosine kinase 1Cancer researchImmune systemAngiogenesisTumor microenvironmentBiologySphingosineImmune checkpointMedicineImmunologyInternal medicineSphingosine-1-phosphateImmunotherapyReceptorSphingolipid Metabolism and SignalingImmune cells in cancerDrug Transport and Resistance Mechanisms