Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy
Fengying Lu, Zhengjun Li, Yong Kang, Zhiguo Su, Rong Yu, Songping Zhang
Abstract
, thus endowing the WPU-BPQDs-boosted production of ROS as compared to the bare BPQDs. Considering the undesired acidic tumor environment, this unique pH regulation effect of WPU-BPQDs would be beneficial for in vivo photodynamic efficacy. Both in vitro and in vivo experiments showed that WPU-BPQDs could effectively improve photodynamic therapy (PDT) and maintain outstanding photothermal therapy (PTT) effects. Together with the excellent dispersity, biocompatibility, and easy biodegradability, WPU-BPQDs can be a promising agent for PDT/PTT cancer treatments.
Topics & Concepts
Black phosphorusPolyurethaneMaterials scienceNanoparticleReactive oxygen speciesBiocompatible materialNanotechnologyQuantum dotCancer therapyChemical engineeringCancerComposite materialChemistryBiomedical engineeringOptoelectronicsMedicineInternal medicineEngineeringBiochemistryNanoplatforms for cancer theranostics2D Materials and ApplicationsAdvanced Nanomaterials in Catalysis