Trafficking of JC virus-like particles across the blood–brain barrier
Dong Ye, Tina Zimmermann, Victoria Demina, Sergey Sotnikov, Christian Ried, Harri Rahn, Marcus Stapf, Christopher Untucht, Michael Rohe, Georg C. Terstappen, Karsten Wicke, Mario Mezler, Heiko Manninga, Axel H. Meyer
Abstract
. VLPs were found to interact with sialic acid glycans in mouse brain endothelia. The ability of JC VLPs to cross the BBB can be useful in developing a delivery system for transport of genes and small molecule cargoes to the brain.
Topics & Concepts
Blood–brain barrierVirusVirologyBiologyNeuroscienceCentral nervous systemPolyomavirus and related diseasesFull-Duplex Wireless CommunicationsEnergy Harvesting in Wireless Networks