Newly designed compounds from scaffolds of known actives as inhibitors of survivin: computational analysis from the perspective of fragment-based drug design
Olusola Olalekan Elekofehinti, Opeyemi Iwaloye, Femi Olawale, Prosper Obed Chukwuemeka, Ibukun Mary Folorunso
Topics & Concepts
PharmacophoreSurvivinDocking (animal)ChemistryStereochemistryHOMO/LUMOCombinatorial chemistryComputational chemistryComputational biologyBiochemistryMoleculeApoptosisBiologyOrganic chemistryMedicineNursingCell death mechanisms and regulationComputational Drug Discovery MethodsSynthesis and biological activity