Combinatorial therapy using RNAi and curcumin nano-architectures regresses tumors in breast and colon cancer models
Aviral Kumar, Amarnath Singam, Guruprasadh Swaminathan, Naresh Killi, Naveen Kumar Tangudu, Jedy Jose, G. V. N. Rathna, Lekha Dinesh Kumar
Abstract
in autochthonous knockout models of breast and colon cancer. While mammary tumors showed a considerable decrease in size, oral administration of the biodrug conjugate to Apc knockout colon models prolonged the animal survival period by six months. Hence, this study has provided empirical proof that the combinatorial approach involving RNA interference and nanotechnology is a promising alliance for next-generation cancer therapeutics.
Topics & Concepts
NanocarriersRNA interferenceSmall hairpin RNACurcuminGene silencingBreast cancerCancer researchCancerColorectal cancerSmall interfering RNAReceptor tyrosine kinaseMedicinePharmacologyGene knockdownBiologyDrugRNAGeneInternal medicineReceptorBiochemistryRNA Interference and Gene DeliveryCurcumin's Biomedical ApplicationsMicroRNA in disease regulation