Modular functionalization and hydrogel formation <i>via</i> red-shifted and self-reporting [2+2] cycloadditions
Simon Ludwanowski, Daniel Hoenders, Kubra Kalayci, Hendrik Frisch, Christopher Barner‐Kowollik, Andreas Walther
Abstract
We present a modularly applicable, red-shifted and self-reporting photodynamic covalent crosslinker, abbreviated qStyPy, that performs [2+2] cycloadditions upon irradiation with 470 nm in water. The rational design of qStyPy increases its hydrophilicity due to a permanent charge and features a broad emission in the far-red/near-infrared regime as a readout for the cycloadduct formation, rendering qStyPy suitable for biomedical applications.
Topics & Concepts
Surface modificationModular designChemistryCovalent bondSolubilityPhotodynamic therapyCombinatorial chemistryPolymer chemistryOrganic chemistryComputer sciencePhysical chemistryOperating systemPhotochromic and Fluorescence ChemistrySupramolecular Self-Assembly in MaterialsPhotoreceptor and optogenetics research