Bilobalide alleviates neuroinflammation and promotes autophagy in Alzheimer's disease by upregulating lincRNA-p21.
Yiren Qin, Changdi Ma, Da‐Peng Wang, Quan-Quan Zhang, Meirong Liu, Hongru Zhao, Jianhua Jiang, Qi Fang
Abstract
experiments revealed that bilobalide improved the learning and memory capabilities of APP/PS1 AD mice. Bilobalide improves the cognitive functions of APP/PS1 AD mice. Mechanistically, bilobalide suppresses inflammatory responses and promotes autophagy possibly by upregulating lincRNA-p21 levels.
Topics & Concepts
NeuroinflammationAutophagyDiseaseDownregulation and upregulationMedicineCancer researchCell biologyNeuroscienceBiologyGeneticsInternal medicineApoptosisGeneAutophagy in Disease and TherapyNeurological Disease Mechanisms and TreatmentsMicroRNA in disease regulation