LONP1 downregulation with ageing contributes to osteoarthritis via mitochondrial dysfunction
Yuzhe He, Qianhai Ding, Wenliang Chen, Changjian Lin, Lujie Ge, Chenting Ying, Kai Xu, Zhipeng Wu, Langhai Xu, Jisheng Ran, Weiping Chen, Lidong Wu
Topics & Concepts
Cell biologyMitochondrionMitophagyBiologyDownregulation and upregulationOxidative stressGene knockdownProgrammed cell deathRetrograde signalingSenescenceApoptosisAutophagyEndocrinologyBiochemistryGeneOsteoarthritis Treatment and MechanismsPeroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism