ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model
Koen Vandyck, Rana Abdelnabi, Kusum Gupta, Dirk Jochmans, Andreas Jekle, Jérôme Deval, Dinah Misner, Dorothée Bardiot, Caroline S. Foo, Liu C, Suping Ren, Leonid Beigelman, Lawrence M. Blatt, Sandro Boland, Laura Vangeel, Steven Dejonghe, Patrick Chaltin, Arnaud Marchand, Vladimir Serebryany, Antitsa Stoycheva, Sushmita Chanda, Julian Symons, Pierre Raboisson, Johan Neyts
Topics & Concepts
In vivoHamsterIC50VirologyCysteine proteasePharmacologyCathepsin LCathepsinProteaseVirusIn vitroChemistryBiologyEnzymeMolecular biologyBiochemistryBiotechnologySARS-CoV-2 and COVID-19 Researchinterferon and immune responsesRNA and protein synthesis mechanisms