Extracellular vesicle–encapsulated IL-10 as novel nanotherapeutics against ischemic AKI
Tao‐Tao Tang, Bin Wang, Min Wu, Zuo‐Lin Li, Feng Ye, Jing-Yuan Cao, Di Yin, Hong Liu, Ri‐Ning Tang, Steven D. Crowley, Lin‐Li Lv, Bi‐Cheng Liu
Abstract
EVs efficiently drove M2 macrophage polarization by targeting macrophages in the tubulointerstitium. Our study demonstrates that EVs can serve as a promising delivery platform to manipulate IL-10 for the effective treatment of ischemic AKI.
Topics & Concepts
Extracellular vesicleExtracellular vesiclesExtracellularChemistryCell biologyMicrovesiclesBiologyGeneBiochemistrymicroRNAExtracellular vesicles in diseaseAdvanced Nanomaterials in CatalysisAcute Kidney Injury Research