Effect of metal ions on Alzheimer's disease
Fan Liu, Zhuo Zhang, Lin Zhang, Ruo‐Ni Meng, Jia Ying Gao, Ming Jin, Ming Li, Xiao‐Peng Wang
Abstract
Alzheimer's disease (AD) is a degenerative disease of the nervous system. The typical pathological changes of AD are Aβ deposition, neurofibrillary tangles, neuron loss, and chronic inflammation. The balance of metal ions is essential for numerous physiological functions, especially in the central nervous system. More studies showed that metal ions participate in the development of AD. However, the involvement of metal ions in AD is controversial. Thus, we reviewed articles about the relationship between metal ions and AD and discussed some contradictory reports in order to better understand the role of metal ions in AD.
Topics & Concepts
DiseaseMetal ions in aqueous solutionAlzheimer's diseaseCentral nervous systemInflammationNervous systemNeurosciencePathologicalIonChemistryMedicineInternal medicineBiologyOrganic chemistryAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesTrace Elements in Health