Antihyperglycemic effect of an anthocyanin, cyanidin-3-<i>O</i>-glucoside, is achieved by regulating GLUT-1<i>via</i>the Wnt/β-catenin-WISP1 signaling pathway
Xiang Ye, Wen Chen, Pengcheng Tu, Ruoyi Jia, Yangyang Liu, Qiong Tang, Chuan Chen, Caihong Yang, Xiaodong Zheng, Qiang Chu
Abstract
We suggest that C3G promotes glucose uptake in liver cells by modulating the Wnt/β-catenin-WISP1 pathway to upregulate the expression of GLUT-1 associated with binding to β-catenin to enhance the signal transduction of the Wnt/β-catenin pathway.
Topics & Concepts
Wnt signaling pathwayGlucose transporterIn vivoChemistryDownregulation and upregulationGlycogenCarbohydrate metabolismGlycogen synthaseIn vitroCateninEndocrinologySignal transductionInternal medicineCell biologyPharmacologyBiochemistryBiologyMedicineInsulinGeneGeneticsNatural Antidiabetic Agents StudiesPhytochemicals and Antioxidant ActivitiesWnt/β-catenin signaling in development and cancer