Computational, in vitro and radiation-based in vivo studies on acetamide quinazolinone derivatives as new proposed purine nucleoside phosphorylase inhibitors for breast cancer
Mostafa G M El-Gazzar, Mostafa M. Ghorab, Mohamed A. Amin, Mohamed Korany, Mohammed A. Khedr, Marwa G. El‐Gazzar, Tamer M. Sakr
Topics & Concepts
ChemistryQuinazolinoneAcetamideCytotoxicityADMEPurine nucleoside phosphorylaseQuinazolineStereochemistryIn vitroCombinatorial chemistryPurineBiochemistryEnzymeOrganic chemistryBiochemical and Molecular ResearchPeptidase Inhibition and AnalysisCAR-T cell therapy research