First live birth in China after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency
Xiangyan Ruan, Juan Du, Dan Lu, W. Duan, Fang Jin, Weimin Kong, Ying Wu, Yinmei Dai, Shengtao Yan, Chenghong Yin, Y. Li, Jiumei Cheng, Cuiyu Jia, X. Liu, Qingqing Wu, M. Gu, R. Ju, Xiyuan Xu, Yingchi Yang, Jiayan Jin, M. Korell, Markus Montag, Jana Liebenthron, A. O. Mueck
Abstract
OBJECTIVE: This article reports the first live birth after cryopreserved ovarian tissue transplantation to prevent premature ovarian insufficiency in China. METHODS: A patient with myelodysplastic syndrome received ovarian tissue cryopreservation before hematopoietic stem cell transplantation, and six ovarian cortex strips were thawed and transplanted into her peritoneal pocket 2 years later. RESULTS: Pregnancy occurred spontaneously 27 months after grafting, and a healthy girl was born at 38 weeks gestation. Until now, the child has developed normally without any major diseases. CONCLUSIONS: We report the first live birth resulting from ovarian tissue cryopreservation and transplantation in China.