Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation
Liping Zuo, Jingjing Ding, Changkun Li, Feng Lin, Peng R. Chen, Peilin Wang, Guihong Lu, Jinfeng Zhang, Lili Huang, Hai‐Yan Xie
Abstract
responding to two special tumor microenvironments, with Dox-TCO and Tz released and then immediately triggering the prodrug activation through the IEDDA reaction. The hierarchically regulated and locally confined Dox liberation led to dramatically decreased side-effects that were much lower than those of the clinical Doxorubicin Hydrochloride Liposomal Injection (Doxil), while the antitumor therapeutic effect was potent.
Topics & Concepts
Bioorthogonal chemistryTumor microenvironmentProdrugNanocarriersChemistryBiophysicsDrug deliveryTumor cellsCancer researchBiochemistryCombinatorial chemistryClick chemistryBiologyOrganic chemistryClick Chemistry and ApplicationsPeptidase Inhibition and AnalysisNanoplatforms for cancer theranostics