Light-Promoted and Tertiary-Amine-Assisted Hydroxysulfenylation of Alkenes: Selective and Direct One-Pot Synthesis of β-Hydroxysulfides
Jing Shi, Xue‐Wang Gao, Qing‐Xiao Tong, Jian‐Ji Zhong
Abstract
A light-promoted and tertiary-amine-assisted strategy for efficient hydroxysulfenylation of both electron-rich and electron-deficient alkenes with thiophenols to selectively and directly access β-hydroxysulfides in one pot is described herein. In contrast to the previously reported thiol-oxygen co-oxidation reactions, this simple and sustainable approach features mild reaction conditions, high efficiency, and excellent functional group tolerance.
Topics & Concepts
Amine gas treatingTertiary amineChemistryFunctional groupThiolCombinatorial chemistryPhotochemistryOrganic chemistryPolymerSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsRadical Photochemical Reactions