PhpC modulates G-quadruplex-RNA landscapes in human cells
Jérémie Mitteaux, Sandy Raevens, Zi Wang, Marc Pirrotta, Ibai E. Valverde, Robert H. E. Hudson, David Monchaud
Abstract
Stabilizing DNA/RNA G-quadruplexes (G4s) using small molecules (ligands) has proven an efficient strategy to decipher G4 biology. Quite paradoxically, this search has also highlighted the need for finding molecules able to disrupt G4s to tackle G4-associated cellular dysfunctions. We report here on both qualitative and quantitative investigations that validate the G4-RNA-destabilizing properties of the leading compound PhpC in human cells.
Topics & Concepts
G-quadruplexRNAChemistryComputational biologyCell biologyDNABiophysicsBiologyNanotechnologyBiochemistryGeneMaterials scienceDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery