Synthesis, Characterization, and Antimicrobial Activity of Rh<sup>III</sup> and Ir<sup>III</sup> N-Heterocyclic Carbene Piano-Stool Complexes
Chad M. Bernier, Christine M. DuChane, Justin S. Martinez, Joseph O. Falkinham, Joseph S. Merola
Abstract
A series of RhIII and IrIII piano-stool complexes of the form [(η5-Cp*R)M(NHC)Cl2] was synthesized and characterized, including 12 X-ray crystallographic structures. The antimicrobial properties of these complexes were screened against a variety of microbes, with several achieving high activities, most notably against Mycobacterium smegmatis (MICs as low as 0.45 μM). In general, the Rh complexes were more potent than their Ir analogues, and activity increased with the hydrophobicity of the Cp*R and NHC ligands.
Topics & Concepts
ChemistryCarbeneAntimicrobialMycobacterium smegmatisMedicinal chemistryStereochemistryCatalysisOrganic chemistryMycobacterium tuberculosisTuberculosisPathologyMedicineN-Heterocyclic Carbenes in Organic and Inorganic ChemistrySynthetic Organic Chemistry MethodsCatalytic Cross-Coupling Reactions