[Pathological changes of the spleen in ten patients with coronavirus disease 2019(COVID-19) by postmortem needle autopsy].
Xia Xu, Xiaona Chang, Huaxiong Pan, Hua Su, Bo Huang, Ming Yang, Dangju Luo, Mixia Weng, Lin Ma, Xiu Nie
Abstract
The death of COVID-19 occurs mainly in the elderly, and some cases have no underlying diseases. Spleen may be one of the organs directly attacked by the virus in some patients who died from COVID-19. T and B lymphocyte in the spleen decrease in varying degrees, lymphoid follicles are atrophied, decreased or absent, and the number of NK cells do not change significantly. And the pathological changes of the spleen are not related to the use of low dose corticosteroid, which may be related to the direct attack of virus and the attack of immune system on its own tissues.
Topics & Concepts
SpleenMedicinePathologyWhite pulpRed pulpAutopsyH&E stainPathologicalHistopathologyWhite blood cellLymphocyteGastroenterologyImmunohistochemistryInternal medicineCOVID-19 and healthcare impactsHematological disorders and diagnosticsAbdominal Trauma and Injuries