Tumor-draining lymph node-derived tumor-specific memory CD8+ T cells: a key player in PD-1/PD-L1 immunotherapy
Enzhi Yin, Nan Sun, Jie He
Abstract
A new study by Huang et al. in Cell identified the presence of tumor-specific memory CD8 + T cells in tumor-draining lymph nodes (TdLNs) and confirmed the critical role of this population in PD-1/PD-L1 immune checkpoint therapy for cancer. 1 The work enriched our understanding of tumor-specific CD8 + T cell subsets and further refined the spatiotemporal mechanism of the antitumor effects of PD-1/PD-L1 immune checkpoint blockade (ICB).
Topics & Concepts
ImmunotherapyLymph nodeCD8Cytotoxic T cellLymphKey (lock)Cancer researchMedicineImmunologyPathologyBiologyImmune systemBiochemistryIn vitroEcologyCancer Immunotherapy and BiomarkersCAR-T cell therapy researchImmunotherapy and Immune Responses