Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling
Julian Wilke, Tatsuro Kawamura, Hao Xu, Alexandra Brause, Alexandra Friese, Malte Metz, Dirk Schepmann, Bernhard Wünsch, Antonia Artacho-Cordón, Francisco R. Nieto, Nobumoto Watanabe, Hiroyuki Osada, Slava Ziegler, Herbert Waldmann
Topics & Concepts
Computational biologySmall moleculeProfiling (computer programming)ProteomeDerivatizationBiologyChemistryBioinformaticsMass spectrometryComputer scienceBiochemistryChromatographyOperating systemPharmacological Receptor Mechanisms and EffectsReceptor Mechanisms and SignalingNicotinic Acetylcholine Receptors Study