Structural Basis of Ligand Selectivity by a Bacterial Adhesin Lectin Involved in Multispecies Biofilm Formation
Shuaiqi Guo, Tyler D. R. Vance, Hossein Shahbani Zahiri, Robert Eves, Corey A. Stevens, Jan‐Hendrik Hehemann, Silvia Vidal‐Melgosa, Peter L. Davies
Abstract
, homologs of which are found in both environmental and pathogenic species. The lectin-ligand interactions illustrated at the atomic level guided the identification of a ligand that serves as an inhibitor to block bacterium-host adhesion. With conventional bactericidal antibiotics losing their potency due to resistance, our work gives critical insight into an antiadhesion strategy to treat bacterial infections.
Topics & Concepts
Bacterial adhesinBiofilmLectinMicrobiologyChemistryLigand (biochemistry)BiologyCell biologyBacteriaBiochemistryComputational biologyEscherichia coliReceptorGeneGeneticsBiochemical and Structural CharacterizationGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and Synthesis