Studies on interaction potency model based on drug synergy and therapeutic potential of triple stimuli-responsive delivery of doxorubicin and 5-fluoro-2-deoxyuridine against lymphoma using disulfide-bridged cysteine over mesoporous silica nanoparticles
Prateek Srivastava, Sumit Kumar Hira, Ankush Paladhi, Ranjeet Singh, Uttam Gupta, Divesh N. Srivastava, Ram Singh, Partha Pratim Manna
Abstract
T cells, natural killer cells and the dendritic cells from the treated group following successful therapy with the novel construct showed enhanced cytotoxicity and growth inhibitory capacities against DL tumor cells.
Topics & Concepts
PotencyDoxorubicinPharmacologyCysteineDrug deliveryDisulfide bondCombinatorial chemistryMesoporous silicaCancer researchChemistryMedicineMaterials scienceNanotechnologyBiochemistryIn vitroChemotherapyMesoporous materialInternal medicineCatalysisEnzymeNanoparticle-Based Drug DeliveryDendrimers and Hyperbranched PolymersNanoplatforms for cancer theranostics